hHR23b Antibody

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Western Blot: hHR23b Antibody [NB600-620] - Analysis of a band at 58 kDa (arrowhead) corresponding to HR23B present in a HeLa whole cell lysate. Pre-incubation of antibody with immunizing peptide completely blocks ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB600-620
    • Availability
      Product Discontinued

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hHR23b Antibody Summary

Immunogen
Synthetic peptide: CATDSTSGDSSRSNL, corresponding to amino acids 163-176 of Human hHR23b.
Specificity
hHR23b
Clonality
Polyclonal
Host
Goat
Gene
RAD23B
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:2000
  • ELISA 1:2000-1:10000
Application Notes
This affinity purified antibody has been tested for use in ELISA and by western blot. Expect a band approximately 58 kDa in size corresponding - HR23B by western blotting in the appropriate cell lysate or extract.

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative
0.01% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for hHR23b Antibody

  • HHR23B
  • HR23BUV excision repair protein RAD23 homolog B
  • P58
  • RAD23 (S. cerevisiae) homolog B
  • RAD23 homolog B (S. cerevisiae)
  • RAD23, yeast homolog of, B
  • XP-C repair complementing complex 58 kDa
  • XP-C repair complementing protein
  • XP-C repair-complementing complex 58 kDa protein

Background

hHR23b is thought to be involved in DNA excision repair. The protein may play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. hHR23b was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol RAD23B
Entrez