HGS [p Tyr216] Antibody

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Western Blot: HGS [p Tyr216] Antibody [NBP2-13027] - Extracts from A549 cells.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Concentration
1 mg/ml

Order Details

HGS [p Tyr216] Antibody Summary

Immunogen
Synthetic phosphopeptide derived from human Hrs around the phosphorylation site of Tyrosine 216.
Modification
p Tyr216
Specificity
p-Hrs (Y216) detects endogenous levels of p-Hrs (Y216)protein.
Clonality
Polyclonal
Host
Rabbit
Gene
HGS
Purity
Immunogen affinity purified
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Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Conjugate
Unconjugated
Buffer
PBS (approx. pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
Application Notes
Western blot (WB) analysis of p-Hrs (Y216) pAb in extracts from A549 cells.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
86 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross reacts with Human, Mouse and Rat.

Alternate Names for HGS [p Tyr216] Antibody

  • FLJ39878
  • hepatocyte growth factor-regulated tyrosine kinase substrate
  • Hrs
  • HRSFLJ11421
  • human growth factor-regulated tyrosine kinase substrate
  • Protein pp110
  • Vps27
  • ZFYVE8

Background

Hrs is involved in intracellular trafficking and signal transduction and is associated with early endosomes. Hrs contains a phosphatidylinositol 3-phosphate-binding domain that contributes to its endosomal targeting, where Hrs co-localizes with Clathrin via a Clathrin box motif at the carboxy-terminus of Hrs. Hrs is essential for ventral folding morphogenesis and shares structual similarity to the yeast protein Vps27p, which is involved in vacuolar protein sorting. The human Hrs gene, which maps to chromosome 17q25, enodes a 777 amino acid protein. In Schwann cells, Hrs co-localizes at endosomes with the tumor suppressor protein schwannomin, suggesting a role for schwannomin in Hrs-mediated cell signaling.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Contact Information

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Bioinformatics

Gene Symbol HGS

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