HGF R/c-MET Antibody

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Immunohistochemistry-Paraffin: HGF R/c-MET Antibody [NBP1-35680] - Human Ovarian Carcinoma

Product Details

Summary
Product Discontinued
View other related HGF R/c-MET Primary Antibodies

Order Details


    • Catalog Number
      NBP1-35680
    • Availability
      Product Discontinued

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HGF R/c-MET Antibody Summary

Immunogen
A synthetic peptide from C-terminus of human c-Met protein
Localization
Cytoplasm and membrane
Specificity
This product is specific for c-Met
Clonality
Polyclonal
Host
Rabbit
Gene
MET
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50

Reactivity Notes

This product is specific for Human. Predicted to cross-reactivity based on sequence homology: Bovine, Chicken, Dog, Frog, Mouse, Pig, Rabbit, and Rat.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.6) and 1.0% BSA
Preservative
0.099% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for HGF R/c-MET Antibody

  • AUTS9
  • cMET
  • c-MET
  • EC 2.7.10
  • EC 2.7.10.1
  • hepatocyte growth factor receptor
  • HGF R
  • HGF receptor
  • HGF/SF receptor
  • HGFR
  • Met (c-Met)
  • met proto-oncogene (hepatocyte growth factor receptor)
  • met proto-oncogene tyrosine kinase
  • MET
  • oncogene MET
  • Proto-oncogene c-Met
  • RCCP2
  • Scatter factor receptor
  • SF receptor
  • Tyrosine-protein kinase Met

Background

Met is a receptor protein-tyrosine kinase (RPTK) for hepatocyte growth factor (HGF), which is a multifunctional cytokine controlling cell growth, morphogenesis, and motility. Met overexpression has been identified in a variety of human cancers (1). Met kinase domain possesses unique features that distinguish met from other members of the src family of protein tyrosine kinases. These results also demonstrate that the product of the activated met gene is a fusion protein and that the amino terminal end of this fusion protein exhibits homology to laminin B1 (2). Data suggest that RanBP9, functioning as an adaptor protein for the Met tyrosine kinase domain, can augment the HGF-Met signaling pathway and that RanBP9 overexpression may cause constitutive activation of the Ras signaling pathway (1). Hereditary papillary renal carcinoma (HPRC) is a recently recognized form of inherited kidney cancer Results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the Met protein and papillary renal carcinomas (3)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MET
Entrez
Uniprot