HGF R/c-MET Antibody (SP59)

Images

 
Immunohistochemistry-Paraffin: HGF R/c-MET Antibody (SP59) [NBP1-49821] - Human Breast Carcinoma
Immunohistochemistry-Paraffin: HGF R/c-MET Antibody (SP59) [NBP1-49821] - Human Colon.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clone
SP59
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

HGF R/c-MET Antibody (SP59) Summary

Immunogen
Synthetic peptide corresponding to the region of c-Met that contains non-phosphorylated tyrosine1003
Localization
Membrane
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
MET
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
For IHC-P antigen retrieval, boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
7.0 ml prediluted antibody with PBS (pH 7.6) and 1.0% BSA
Preservative
0.1% Sodium Azide
Purity
Protein A purified

Notes

For a positive control use Breast carcinoma.

Alternate Names for HGF R/c-MET Antibody (SP59)

  • AUTS9
  • cMET
  • c-MET
  • EC 2.7.10
  • EC 2.7.10.1
  • hepatocyte growth factor receptor
  • HGF R
  • HGF receptor
  • HGF/SF receptor
  • HGFR
  • Met (c-Met)
  • met proto-oncogene (hepatocyte growth factor receptor)
  • met proto-oncogene tyrosine kinase
  • MET
  • oncogene MET
  • Proto-oncogene c-Met
  • RCCP2
  • Scatter factor receptor
  • SF receptor
  • Tyrosine-protein kinase Met

Background

Met is a receptor protein-tyrosine kinase (RPTK) for hepatocyte growth factor (HGF), which is a multifunctional cytokine controlling cell growth, morphogenesis, and motility. Met overexpression has been identified in a variety of human cancers (1). Met kinase domain possesses unique features that distinguish met from other members of the src family of protein tyrosine kinases. These results also demonstrate that the product of the activated met gene is a fusion protein and that the amino terminal end of this fusion protein exhibits homology to laminin B1 (2). Data suggest that RanBP9, functioning as an adaptor protein for the Met tyrosine kinase domain, can augment the HGF-Met signaling pathway and that RanBP9 overexpression may cause constitutive activation of the Ras signaling pathway (1). Hereditary papillary renal carcinoma (HPRC) is a recently recognized form of inherited kidney cancer Results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the Met protein and papillary renal carcinomas (3)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for HGF R/c-MET Antibody (NBP1-49821). (Showing 1 - 1 of 1 FAQ).

  1. What would you recommend for the starting dilution for c-Met Antibody (SP59) in IHC (Paraffin)?
    • We recommend a starting dilution of 1:100 and then optimizing from there. The optimal dilution will vary depending on your tissues and experimental conditions.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol MET
Entrez
Uniprot