Hepatitis C Virus Core Antigen Antibody (B055M)

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Order Details


    • Catalog Number
      NB110-68198
    • Availability
      Product Discontinued

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Hepatitis C Virus Core Antigen Antibody (B055M) Summary

Immunogen
Recombinant HCV core antigen, genotype 1a.
Specificity
Hepatitis C Virus (HCV) Core Antigen. Reactive with genotypes 1a and 2. (B055M)
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
HCVgp1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
Application Notes
Suitable for use in ELISA. Does not work in Western blot or IFA. Use NB110-68197 or NB110-68196 as the detection antibody and NB110-68198 as the capture antibody.

Reactivity Notes

Hepatitis C Virus

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM PBS (pH 7.2)
Preservative
No Preservative
Concentration
0.1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Hepatitis C Virus Core Antigen Antibody (B055M)

  • Core protein p19
  • HCcAg
  • HCV core antigen
  • HCV core protein

Background

The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Additional Hepatitis C Virus Core Antigen Products

Hepatitis C Virus Core Antigen NB110-68198

Bioinformatics Tool for Hepatitis C Virus Core Antigen Antibody (NB110-68198)

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Bioinformatics

Gene Symbol HCVgp1