HDAC9 Overexpression Lysate (Denatured)

Product Discontinued

HDAC9 Overexpression Lysate (Denatured) Summary

• Description: Quality control test: Transient overexpression cell lysate was tested with Anti-HDAC9 antibody by Western Blots. Plasmid: pCMV-HDAC9 full-length
• Gene: HDAC9

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, and 0.01% Bromophenol blue).

Lysate Details for Array

• Type: Overexpression
• Protein State: Denatured

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for HDAC9 Overexpression Lysate (Denatured)

• EC 3.5.1.98
• HD7b
• HD7HDAC
• HD9
• HDAC7
• HDAC7B
• HDAC7BDKFZp779K1053
• HDAC9
• HDRP
• histone deacetylase 4/5-related protein
• Histone deacetylase 7B
• histone deacetylase 9
• Histone deacetylase-related protein
• KIAA0744
• KIAA0744HDAC9B
• MEF-2 interacting transcription repressor (MITR) protein
• MEF2-interacting transcription repressor MITR
• MITR
• MITRHDAC9FL

Background

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Lysates are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: HDAC9