HDAC6 Antibody

Product Discontinued

HDAC6 Antibody Summary

• Immunogen: Synthetic peptide: KNIAHQNKFGEDMPH conjugated to KLH, corresponding to amino acids 1199-1213 of Human HDAC6.
• Localization: Cytoplasmic and Nuclear
• Specificity: HDAC6
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: HDAC6
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:1000
• Application Notes: IP: Use at an assay dependent dilution. WB: Detects a band of approximately 134 kDa. Additional non-specific bands of approx. 50 kDa may be detected in various extract preparations. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
• Control:

  HDAC6 Overexpression Lysate

Reactivity Notes

Cross-reacts with Human and Mouse. Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Purity: IgG purified

Alternate Names for HDAC6 Antibody

• CPBHM
• EC 3.5.1.98
• FLJ16239
• HD6
• HD6FLJ16239
• HDAC6
• Histone Deacetylase 6
• JM21
• KIAA0901
• PPP1R90

Background

HDAC6 is a member of the class II mammalian histone deacetylases. Human HDAC6 is composed of 1215 amino acid residues. It possesses two separate putative catalytic domains. Both catalytic domains are fully functional HDACs and contribute independently to the overall activity of HDAC6 protein. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. The expression of HDAC6 is tightly linked to the state of cell differentiation. HDAC6 may participate in coordinating expression of a group of genes involved in the remodelling of chromatin during cell differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Review for HDAC6 Antibody (NB120-12173) (1)

Average Rating: 4

(Based on 1 review)

We have 1 review tested in 1 species: Human.

reviewed by: Verified Customer WB Human 12/30/2011

Summary

• Application: Western Blot
• Sample Tested: Human
• Species: Human

Bioinformatics

• Gene Symbol: HDAC6
• Entrez:
  • 10013(Human)
  • 15185(Mouse)