HCLS1 Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-66193
    • Availability
      Product Discontinued

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HCLS1 Antibody Summary

Immunogen
Peptide sequence HFGLFPANYVKLLE corresponding to the C-terminus of HCLS1 (NP_005326).
Specificity
NB100-66193 recognizes human haematopoietic cell-specific lyn substrate 1 (HCLS1), a 75KD intracellular protein involved in the signal transduction pathways in lymphocytes. Expression of HCLS1 is restricted to cells of haematopoietic origin and is expressed in early stages of myeloid and erythroid differentiation.
Clonality
Polyclonal
Host
Goat
Gene
HCLS1
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • Western Blot 2 ug/ml-4 ug/ml
Application Notes
Western Blot detects a band of approximately 70-75kDa in Raji cell lysates. An overnight incubation time of 12 hours is recommended for this antibody.

Reactivity Notes

Human. Based on sequence similarity, is expected to react with Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
TBS (pH 7.3)
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
IgG purified

Alternate Names for HCLS1 Antibody

  • Cortactin-like
  • CTTNL
  • HCLS1
  • hematopoietic cell-specific Lyn substrate 1hematopoietic lineage cell-specific protein
  • HS1lckBP1
  • LckBP1
  • p75

Background

Hematopoietic cell specific Lyn substrate 1 (HCLS1) is an intracellular protein involved in the signal transduction pathways in B and T lymphocytes. HCLS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets. The gene is a substrate for caspase cleavage during apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Discover related pathways, diseases and genes to HCLS1 Antibody (NB100-66193). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Bioinformatics

Gene Symbol HCLS1
Entrez
Uniprot