hCG holo C2 Antibody (HCGab/52)

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Immunohistochemistry-Paraffin: hCG holo C2 Antibody (HCGab/52) [NBP2-45334] - Human Placenta stained with hCG Monoclonal Antibody (HCGab/52).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC-P
Clone
HCGab/52
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

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Catalog# & Formulation Size Price

hCG holo C2 Antibody (HCGab/52) Summary

Immunogen
Purified hCG protein
Localization
Cytoplasmic, Secreted
Marker
Pregnancy & Choriocarcinoma Marker
Specificity
This MAb is a very special because it reacts ONLY with the intact-HCG and not with either free alpha- or free beta-chain of HCG. HCG is a glycoprotein and is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and beta subunits. The alpha subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). HCG is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. HCG expression by non-trophoblastic tumors may indicate aggressive behavior.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml
Application Notes
Hu-chromosome location: 6q12-q21 (HCG-alpha) & 19q13.33 (HCG-beta)
Molecular weight of antigen: ~35kDa (intact hCG)
Immunohistochemistry-Paraffin 0.5 - 1 ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10 - 20 min followed by cooling at RT for 20 minutes.

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
10mM PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for hCG holo C2 Antibody (HCGab/52)

  • choriogonadotropin subunit beta
  • CGB3
  • CGB5
  • CGB7
  • CGB8
  • chorionic gonadotropin, beta polypeptide
  • hCGB

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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