hCG Alpha (Intact) Antibody

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
11.7 mg/ml

Order Details

hCG Alpha (Intact) Antibody Summary

Immunogen
Native hCG
Localization
Secreted
Specificity
This product is specific for human chorionic gonadotrophin (hCG), a 30kD hormone produced by placental syncytiotrophoblasts. hCG acts to maintain the corpus luteum until the developing placenta is able to produce the required levels of oestrogen and progesterone. hCG shares a common alpha chain with the pituitary hormones FSH, TSH and LH, but has a unique beta chain. This antibody reacts with intact hCG.
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
CGA
Purity
IgG purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:500-1:1000
Positive Control
Chorionic Gonadotropin alpha Chain (HCG alpha) Lysate (NBL1-09130)

Reactivity Notes

Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.09% Sodium Azide
Concentration
11.7 mg/ml
Purity
IgG purified

Alternate Names for hCG Alpha (Intact) Antibody

  • glycoprotein hormones alpha chain
  • CG-ALPHA
  • FSHA
  • glycoprotein hormones, alpha polypeptide
  • GPHa
  • GPHA1
  • HCG
  • LHA
  • TSHA

Background

Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. Maintenance of the fetus in the first trimester of pregnancy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. hCG is present only in trace amounts in non pregnant urine and sera. It rises sharply during pregnancy. HCG is composed of two non identical, non covalently linked polypeptide chains designated as the a and b subunits. The a subunit of HCG is nearly identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH) and luteinizing hormone (LH). A germ cell tumor which is positive for cytokeratin, placental alkaline phosphatase (PLAP) and HCG but negative for EMA and AFP is probably a choriocarcinoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CGA
Entrez
Uniprot