HABP1/C1QBP/GC1q R Antibody [Alexa Fluor® 532]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 532

HABP1/C1QBP/GC1q R Antibody [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant mouse HABP1/C1QBP
  Leu72-Gln279
  Accession # NP_031599
• Specificity: Detects human, mouse, and rat HABP1/C1QBP in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human C1QR is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for HABP1/C1QBP/GC1q R Antibody [Alexa Fluor® 532]

• C1q globular domain-binding protein
• C1QBP
• complement component 1 Q subcomponent-binding protein, mitochondrial
• complement component 1, q subcomponent binding protein
• gC1qBP
• GC1q-R protein
• gC1qR
• gC1Q-R
• Glycoprotein gC1qBP
• HABP1
• HABP1p33
• Hyaluronan-binding protein 1
• Mitochondrial matrix protein p32
• p32
• SF2p32
• splicing factor SF2-associated protein

Background

HABP1 (hyaluronan binding protein1; also p32 and gC1qR) is a 33 kDa member of the MAM33 family of proteins. It is widely expressed and found on/in endothelial cells, platelets and dendritic cells. It has multiple binding partners, including complement C1q, hyaluronan, vitronectin and ARF. Full-length mouse HABP1 proprecursor is 279 amino acid (aa) in length. It contains a 70 aa mitochondrial targeting sequence (aa 1‑70) that is cleaved to generate a 209 aa mature segment. A hyaluronan binding site lies between Lys116‑Lys125 and a Tyr phosphorylation site exists at Tyr184. Although the prosegment is usually cleaved, the intact proprecursor is associated with sperm. HABP1 reportedly forms noncovalent homotrimers. Over aa 72‑279, mouse HABP1 shares 99% and 91% aa identity with rat and human HABP1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.