Guanylyl Cyclase beta 1 Antibody

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Immunohistochemistry-Paraffin: Guanylyl Cyclase beta 1 Antibody [NBP1-50179] - Staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-50179
    • Availability
      Product Discontinued

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Guanylyl Cyclase beta 1 Antibody Summary

Immunogen
Synthetic peptide
Specificity
Amino acids 189 to 207 of human GUCY1B3
Clonality
Polyclonal
Host
Rabbit
Gene
GUCY1B3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4) and 0.2% BSA
Preservative
0.05% Sodium Azide
Concentration
0.2 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Guanylyl Cyclase beta 1 Antibody

  • EC 4.6.1.2
  • GC-SB3
  • GCS-beta-1
  • GCS-beta-3
  • guanylate cyclase 1, soluble, beta 3
  • guanylate cyclase soluble subunit beta-1
  • Guanylate cyclase soluble subunit beta-3
  • GUC1B3GUCB3
  • GUCSB3GC-S-beta-1
  • GUCY1B1
  • Soluble guanylate cyclase small subunit

Background

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GUCY1B3
Entrez
Uniprot