Guanylyl Cyclase beta 1 Antibody

Images

 
Western Blot: Guanylyl Cyclase beta 1 Antibody [NB100-91798] - Analysis of Guanylyl Cyclase beta1 (V21) pAb at 1:500 dilution Lane1:THP-1 whole cell lysate Lane2:sp2/0 whole cell lysate Lane3:H9C2 whole cell lysate
Immunohistochemistry-Paraffin: Guanylyl Cyclase beta 1 Antibody [NB100-91798] - Analyzes of paraffin-embedded human breast carcinoma tissue at 1:100.
Western Blot: Guanylyl Cyclase beta 1 Antibody [NB100-91798] - Extracts from HuvEc cells.
Western Blot: Guanylyl Cyclase beta 1 Antibody [NB100-91798] - Analysis of Guanylate Cyclase beta1 (V21) pAb in extracts from PC12 cells.
Immunohistochemistry-Paraffin: Guanylyl Cyclase beta 1 Antibody [NB100-91798] - Human lung carcinoma tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-91798
    • Availability
      Product Discontinued

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Guanylyl Cyclase beta 1 Antibody Summary

Immunogen
Synthetic peptide, corresponding to the N-terminus of Human GCS-beta-1.
Clonality
Polyclonal
Host
Rabbit
Gene
GUCY1B3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of Guanylate Cyclase Beta1/3 (V21) pAb in extracts from PC12 cells.
Immunohistochemistry (IHC) analyzes of Guanylate Cyclase Beta1/3 (V21) pAb in paraffin-embedded human lung carcinoma tissue.
Theoretical MW
70 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
NB100-91798 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Guanylyl Cyclase beta 1 Antibody

  • EC 4.6.1.2
  • GC-SB3
  • GCS-beta-1
  • GCS-beta-3
  • guanylate cyclase 1, soluble, beta 3
  • guanylate cyclase soluble subunit beta-1
  • Guanylate cyclase soluble subunit beta-3
  • GUC1B3GUCB3
  • GUCSB3GC-S-beta-1
  • GUCY1B1
  • Soluble guanylate cyclase small subunit

Background

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Guanylyl Cyclase beta 1 Antibody (NB100-91798)(1)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: WB.


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Video Protocols

WB Video Protocol

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Bioinformatics

Gene Symbol GUCY1B3
Entrez