GRO gamma Antibody

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Immunohistochemistry-Paraffin: GRO gamma Antibody [NBP1-51189] Immunohistochemistry (IHC) analyzes of GROalpha (P88) pAb in paraffin-embedded human heart tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51189
    • Availability
      Product Discontinued

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GRO gamma Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 150-200 of Human GROgamma.
Specificity
GROgamma (N177) pAb detects endogenous levels of GROgamma protein.
Clonality
Polyclonal
Host
Rabbit
Gene
CXCL3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Immunohistochemistry (IHC) analyzes of GROalpha (P88) pAb in paraffin-embedded human heart tissue.
Theoretical MW
11 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GRO gamma Antibody

  • chemokine (C-X-C motif) ligand 3
  • CINC-2b
  • C-X-C motif chemokine 3
  • GRO3 oncogene
  • GRO3MIP2-beta
  • GROg
  • GRO-gamma
  • Growth-regulated protein gamma
  • Macrophage inflammatory protein 2-beta
  • melanoma growth stimulatory activity gamma
  • MGSA gamma
  • MIP2B
  • MIP-2b
  • SCYB3GRO-gamma(1-73)

Background

Growth Regulated Protein gamma (GRO gamma) is a cytokine that may play a role in inflammation and affects endothelial cells in an autocrine fashion. It belongs to the intercrine alpha family (small cytokine c-x-c) (chemokine cxc).Rat CINC2 beta (Cytokine Induced Neutrophil Chemoattractant 2 beta) is a member of the CXC subfamily of chemokines which also includes three other rat CXC chemokines (CINC1, CINC2 alpha, CINC3/MIP2). The rat chemokines CINC show sequence similarity to human GROs and mouse MIP2 but not IL8. Mature CINC2 beta shares 63% amino acid sequence identity with CINC1 and 80% identity to CINC3. Rat CINC2 beta cDNA encodes a 68 amino acid residue protein. The mature recombinant protein has a predicted molecular mass of approximately 7.6 kDa. Based on sequence homology, it has been suggested that CINCs are the rat counterpart of the human GROs. CINC2 alpha and CINC2 beta were originally purified as novel neutrophil chemoattractants from the conditioned medium of rat granulation tissue CINC2 proteins represent the major chemokines purified from conditioned medium of granulation tissue or lipopolysaccharide (LPS) induced inflammatory exudate, though CINC1 and CINC3 are also present. Other cell types known to produce CINC2 proteins include activated macrophages and fibroblasts. Rat CINCs, potent neutrophil attractants and activators, have an important role in the infiltration of neutrophils into inflammatory sites in rats. Recombinant and natural CINC2 proteins are specific neutrophil chemoattractants both in vivo and in vitro. On the basis of cross-desensitization, it has been postulated that rat neutrophils have at least two classes of CINC receptors: a class of CINC3 specific receptor as well as a second common receptor shared by all CINCs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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GRO gamma NBP1-51189

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Bioinformatics

Gene Symbol CXCL3