GRIP1 Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-2824
    • Availability
      Product Discontinued

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GRIP1 Antibody Summary

Immunogen
Synthetic peptide: C-KKQTDAQSASSPKK, representing the internal region of the human protein according to NP_066973.1
Clonality
Polyclonal
Host
Goat
Gene
GRIP1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Peptide ELISA 1:16000
Application Notes
Peptide ELISA: antibody detection limit dilution 1:64000. Western Blot: Preliminary experiments gave an approx 75kDa band in Human Brain lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 116kDa according to NP_066973.1. The 75kDa band was successfully blocked by incubation with the immunizing peptide. We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? Have any further splice variants/modified forms been reported?

Reactivity Notes

Human, mouse, rat and dog.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for GRIP1 Antibody

  • glutamate receptor interacting protein 1
  • glutamate receptor-interacting protein 1
  • GRIP
  • GRIP-1

Background

GRIP1 (Glutamate receptor interacting protein 1) is a scaffold protein composed of seven PDZ domains. The protein plays important roles in the synaptic targeting of AMPA receptors. It also has been shown to interact with HAP1-A, liprin-alpha and LAR receptor protein tyrosine phosphatases. GRIP1 is associated with the cytoplasm and membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. It is enriched in post-synaptic plasma membrane and post-synaptic densities. The palmitoylated form of isoform 2 is exclusively membrane-associated.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol GRIP1
Entrez
Uniprot