Granzyme B Antibody (4F5)

Images

 
Sandwich ELISA: Granzyme B Antibody (4F5) [H00003002-M01] - Detection limit for recombinant GST tagged GZMB is 0.3 ng/ml as a capture antibody.
Immunoprecipitation: Granzyme B Antibody (4F5) [H00003002-M01] - Analysis of GZMB transfected lysate using anti-GZMB monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with GZMB MaxPab rabbit polyclonal ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      H00003002-M01
    • Availability
      Product Discontinued

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Granzyme B Antibody (4F5) Summary

Immunogen
GZMB (AAH30195 148 a.a. - 247 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. GQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTMKRH
Specificity
Reacts with granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1).
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
GZMB
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Immunoprecipitation
Application Notes
This antibody is reactive against recombinant protein in WB and ELISA.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein A purified

Notes

Quality control test: Antibody Reactive Against Recombinant Protein.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Granzyme B Antibody (4F5)

  • CSPB
  • CTLA-1
  • CTSGL1
  • Fragmentin-2
  • Granzyme B
  • Granzyme-2
  • GRB
  • GrzB
  • GZMB
  • HLP
  • SECT

Background

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Granzyme B Antibody (H00003002-M01)

Discover related pathways, diseases and genes to Granzyme B Antibody (H00003002-M01). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on Granzyme B.

Caspase 3, the executioner of apoptosis
Caspase-3 enzyme is a member of the family of endoproteases which regulate inflammation and apoptosis signaling networks. Caspase-3 is known as an executioner caspase in apoptosis because of its role in coordinating the destruction of cellular stru...  Read full blog post.

Caspase 9: The Suicidal Cell Whisperer
Cell death via apoptosis is a key cellular function triggered by the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. Among the subclass of initiator caspases that include...  Read full blog post.

Caspase 7: The Cell's Suicide Switch
Caspase 7 (also known as CASP7, Mch3, ICE-LAP3, CMH-1) is a member of caspase family of cysteine proteases. It is an apoptosis-related cystein peptidase encoded by the CASP7 gene in humans. CASP7 homologous sequences have been identified in nearly all...  Read full blog post.

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Bioinformatics

Gene Symbol GZMB
Entrez
Uniprot