gp130/CD130 Antibody (MP5-32C11)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51783
    • Availability
      Product Discontinued

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gp130/CD130 Antibody (MP5-32C11) Summary

Immunogen
The antibody reacts with Mouse CD130.
Specificity
Anti-mIL-6 specifically neutralizes the biological activity of mouse IL-6. It binds both natural and recombinant murine IL-6 and does not cross-react to either human or rat IL-6.Interleukin 6 (IL-6) is a pluripotent 20-22 kDa cytokine which plays a role in the pathophysiology of severe infection and regulates the immune response, acute phase reaction and haematopoiesis. IL-6 plays a critical role in B-cell differen­tiation to plasma cells and is a potent growth factor for plasmacyto­ma and myeloma. Continuous IL-6 gene expression makes an essential contribu­tion to a multistep oncogenesis of plasma cell neoplasia. IL-6 is a very useful culture supplement for the generation of a high number of antibody producing hybridomas.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
IL6ST
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Blocking/Neutralizing 50-200 molar excess
  • ELISA 1:100-1:2000
  • Immunoprecipitation 1:10-1:500
Application Notes
This antibody can be used for immuno assays, immunoprecipitation and inhibition of biological activity.

Reactivity Notes

Mouse

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Concentration
0.2 mg/ml
Purity
Protein A or G purified

Alternate Names for gp130/CD130 Antibody (MP5-32C11)

  • CD130 antigen
  • CD130
  • CDw130
  • DKFZp564F053
  • gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
  • gp130
  • IL-6 receptor subunit beta
  • IL-6R subunit beta
  • IL-6RB
  • IL-6R-beta
  • IL6ST
  • interleukin 6 signal transducer (gp130, oncostatin M receptor)
  • interleukin receptor beta chain
  • interleukin-6 receptor subunit beta
  • Interleukin-6 signal transducer
  • Membrane glycoprotein 130
  • membrane glycoprotein gp130
  • Oncostatin-M receptor subunit alpha

Background

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol IL6ST
Entrez