This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for gp130/CD130 Antibody (2A4)
gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
IL-6 receptor subunit beta
IL-6R subunit beta
interleukin 6 signal transducer (gp130, oncostatin M receptor)
interleukin receptor beta chain
interleukin-6 receptor subunit beta
Interleukin-6 signal transducer
Membrane glycoprotein 130
membrane glycoprotein gp130
Oncostatin-M receptor subunit alpha
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.