GnRH Antibody

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Immunohistochemistry-Paraffin: GnRH Antibody [NBP1-51205] Immunohistochemistry (IHC) analyzes of GnRH I (D43) pAb in paraffin-embedded human heart tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51205
    • Availability
      Product Discontinued

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GnRH Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 11-60 of Human GnRH I.
Specificity
GnRH I (D43) pAb detects endogenous levels of GnRH I protein.
Clonality
Polyclonal
Host
Rabbit
Gene
GNRH1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Immunohistochemistry (IHC) analyzes of GnRH I (D43) pAb in paraffin-embedded human heart tissue.
Theoretical MW
11 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GnRH Antibody

  • GNRH
  • GnRH-associated peptide 1
  • gonadotropin-releasing hormone 1 (leutinizing-releasing hormone)
  • gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
  • GRH
  • LHRH
  • LNRH
  • luliberin I
  • Progonadoliberin I
  • progonadoliberin-1
  • prolactin release-inhibiting factor

Background

Human reproduction is controlled by the hypothalaic-pituitary gonadal axislaid down early in fetal development. Luteinizing hormone releasing hormone (LHRH), also known as gonadotropin releasing hormone (GnRH), luliberin, gonadorelin or GnRH-associated peptide, is a decapeptide that is an important molecule in the hypothalamic-pituitary-gonadal axis control circuit. GnRH is produced by hypothalamic neurons and secreted in a pulsatile manner into the capillary plexus of the median eminence. GnRH affects the release of lutenizing hormone and follicle stimulating hormone from gonadotropic cells in the anterior pituitary. In addition to hypothalamic GnRH (GnRH I), a second GnRH form (GnRH II) functions primarily in the midbrain. GnRH is xpressed in the acrosomal region of human sperm and in the anterior pituitary tissue and cancer cells. Unlike GnRH I, GnRH II is highly expressed outside the brain, particularly in the kidney, bone marrow and prostate, suggesting that it may have multiple functions. GnRH binds to a specific G protein-coupled receptor in the pituitary to regulate synthesis and secretion of gonadotropins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Blogs on GnRH.

The Use of RNA Polymerase II Antibodies In Proteasome Regulation Studies
At Novus Biologicals, we recently added a new RNA Polymerase II antibody (clone 4H8) to our antibody catalog. RNAPII is an essential transcription enzyme, catalyzing the transcription of DNA during the elongation stage of mRNA synthesis (known as the...  Read full blog post.

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Bioinformatics

Gene Symbol GNRH1