GNB3 Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-2921
    • Availability
      Product Discontinued

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GNB3 Antibody Summary

Immunogen
Peptide with sequence DCMSLAVSPDFN corresponding to internal region according to NP_002066.1.
Specificity
No cross-reactivity expected with GNB1, 2 and 4
Clonality
Polyclonal
Host
Goat
Gene
GNB3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 - 3 ug/ml
  • Peptide ELISA Detection limit 1:1000
Application Notes
WB: Approx. 36 kDa band observed in human brain (frontal cortext) lysates (calculated MW of 37.2 kDa band according to NP_002066.1).
Positive Control
GNB3 Lysate (NBL1-11167)
Publications
Read Publication using NB100-2921.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for GNB3 Antibody

  • G protein, beta-3 subunit
  • GTP-binding regulatory protein beta-3 chain
  • guanine nucleotide binding protein (G protein), beta polypeptide 3
  • guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3
  • guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
  • hypertension associated protein
  • Transducin beta chain 3

Background

G proteins are composed of 3 units, alpha, beta and gamma and are involved in the modulation and transduction of various transmembrane signalling systems. There are families of related genes for each subunit. GNB3 encodes a beta subunit. Beta subunits are required for GTPase activity, for replacement of GDP by GTP, regulate alpha subunits and for G protein-effector interactions. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity and is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for GNB3 Antibody (NB100-2921)(1)


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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GNB3
Entrez
Uniprot