Glutamate Receptor 6 Antibody

Images

 
Western Blot: Glutamate Receptor 6 Antibody [NB100-91786] - Extracts from mouse brain.
Immunohistochemistry-Paraffin: Glutamate Receptor 6 Antibody [NB100-91786] - Paraffin-embedded human brain tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-91786
    • Availability
      Product Discontinued

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Glutamate Receptor 6 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 841-890 of Human mGluR-6.
Specificity
GluR6 detects endogenous levels of GluR6 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
GRIK2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of mGluR6 (A865) pAb in extracts from mouse brain.
Immunohistochemistry (IHC) analyzes of mGluR6 (A865) pAb in paraffin-embedded human brain tissue.
Theoretical MW
100 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Glutamate Receptor 6 Antibody

  • EAA4
  • glutamate receptor 6
  • glutamate receptor, ionotropic, kainate 2
  • ionotropic kainate 2
  • MGC74427

Background

Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamategated, caution-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brain stem, whereas the four epsilon subunits display limited distribution.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GRIK2
Entrez