GluR2/3 Antibody

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Immunohistochemistry-Paraffin: GluR2/3 Antibody [NBP1-35920] - Human Cerebellum.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

GluR2/3 Antibody Summary

Immunogen
A synthetic peptide from c-terminus of human Glutamate Receptor 2/3.
Specificity
This product is specific for Glutamate Receptor 2/3
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRIA2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50

Reactivity Notes

This product is specific for Human, Mouse, Rat, Mk, Avian.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
10mM PBS (pH 7.4)
Preservative
Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for GluR2/3 Antibody

  • AMPA 2
  • GluR2/3
  • glutamate receptor, ionotropic, AMPA 2

Background

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Additional GluR2/3 Products

GluR2/3 NBP1-35920

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Bioinformatics

Gene Symbol GRIA2
Entrez