Glucose Transporter GLUT8 Blocking Peptide

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Order Details


    • Catalog Number
      NBP1-49665PEP
    • Availability
      Product Discontinued

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Glucose Transporter GLUT8 Blocking Peptide Summary

Description
A peptide to SLC2A8.
Immunogen
Synthetic peptide corresponding to unique epitope on Glut 8 protein. The peptide sequence was selected from C-terminal region between amino acids 400-477. The peptide was covalently modified post-synthetically to achieve desired antigenicity before coupling to a carrier protein.
Localization
C-terminal
Protein/Peptide Type
Blocking Peptide
Gene
SLC2A8

Applications/Dilutions

Application Notes
This peptide is useful as a blocking peptide for NBP1-49665.

For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.

Alternate Names for Glucose Transporter GLUT8 Blocking Peptide

  • GLUT-8
  • GLUT8solute carrier family 2 (facilitated glucose transporter) member 8
  • GLUTX1facilitated glucose transporter member 8
  • solute carrier family 2 (facilitated glucose transporter), member 8

Background

Thirteen types of glucose/fructose transport carrier proteins designated as Glut 1-13 facilitate glucose/fructose transport across the cell membrane. Molecular cloning of glucose transporters have identified a family of closely related genes that encodes at least 7 proteins exhibiting high degree of amino acid homology (45%-65%) all in the molecular weight range of 40-60 kDa. Individual members of the Glut family have predicted secondary structure characteristic of 12 membrane spanning domains of other transport carriers. Majority of the differences in sequence homology in Glut proteins occur at 4 hydrophilic domains that may play a role in distinct tissue-specific pattern of expression and targeting. All Glut proteins are glycosylated at or near the C-terminus and are present on either cell surface or in intracellular sites. Some transporters exhibit dynamic trafficking between intracellular storage sites and plasma membranes in response to various stimuli. In some tissues Glut proteins are asymmetrically distributed between apical and basolateral membranes as in blood brain barrier and blood testis barriers. Glut 8 is a insulin regulated glucose facilitative transporter and binds cytocalasin B. The Glut family-selective antibodies were generated against unique C-terminal peptides characteristics of a particular Glut family. Novus has generated highly specific rabbit anti-Glut 8 polyclonal antibodies utilizing mostly C-terminal sequences. These antibodies have been fully characterized for cross reactivity with in the Glut family and with other cellular proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics Tool for Glucose Transporter GLUT8 Peptide (NBP1-49665PEP)

Discover related pathways, diseases and genes to Glucose Transporter GLUT8 Peptide (NBP1-49665PEP). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Glucose Transporter GLUT8 Peptide (NBP1-49665PEP)

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Bioinformatics

Gene Symbol SLC2A8