GITR/TNFRSF18 Antibody (YGL 386)



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GITR/TNFRSF18 Antibody (YGL 386) Summary

This antibody was generated by immunizing host with Recombinant mouse GITRL protein and Transfected cells
B cells, macrophages, dendritic cells, endothelial cells.
IgG1 Kappa
Protein A or G purified
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
Phosphate-buffered solution, pH 7.2,
0.09% Sodium Azide
0.5 mg/ml
Protein A or G purified


Application Notes
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Reactivity Notes



GITR ligand (GITRL) is a member of the TNF sperfamily, also known as TNFSF18 or TL6. It is expressed on B cells, macrophages, dendritic cells and endothelial cells. The expression of GITRL on dendritic cell surface can be transiently up-regulated and then rapidly down-regulated by LPS stimulation. GITRL binds to its receptor, GITR, to co-stimulate T cell activation, proliferation, and cytokine production, and inhibit the suppressive functions of CD4+CD25+ Treg cells, as well as induce macrophages activation. GITR-GITRL interaction has been implicated as an essential regulator of immune response to self antigens and phathogens.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol TNFRSF18

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