GITR/TNFRSF18 Antibody (YGL 386) Summary
This antibody was generated by immunizing host with Recombinant mouse GITRL protein and Transfected cells
B cells, macrophages, dendritic cells, endothelial cells.
Protein A or G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Flow Cytometry 1:10-1:1000
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS (pH 7.2)
0.09% Sodium Azide
Protein A or G purified
Alternate Names for GITR/TNFRSF18 Antibody (YGL 386)
- Activation-inducible TNFR family receptor
- AITRTNF receptor superfamily activation-inducible protein
- CD357 antigen
- GITRtumor necrosis factor receptor superfamily member 18
- Glucocorticoid-induced TNFR-related protein
- tumor necrosis factor receptor superfamily, member 18
GITR ligand (GITRL) is a member of the TNF sperfamily, also known as TNFSF18 or TL6. It is expressed on B cells, macrophages, dendritic cells and endothelial cells. The expression of GITRL on dendritic cell surface can be transiently up-regulated and then rapidly down-regulated by LPS stimulation. GITRL binds to its receptor, GITR, to co-stimulate T cell activation, proliferation, and cytokine production, and inhibit the suppressive functions of CD4+CD25+ Treg cells, as well as induce macrophages activation. GITR-GITRL interaction has been implicated as an essential regulator of immune response to self antigens and phathogens.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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