GITR/TNFRSF18 Antibody (YGITR 765) [FITC] Summary
This antibody was generated by immunizing host with Recombinant mouse GITR protein and Transfected cells
Low levels on resting T cells, high on CD4+CD25+ Treg cells, expression upregulated upon activation.
Protein A or G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Flow Cytometry 1:10-1:1000
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS (pH 7.2)
0.09% Sodium Azide
Protein A or G purified
Alternate Names for GITR/TNFRSF18 Antibody (YGITR 765) [FITC]
- Activation-inducible TNFR family receptor
- AITRTNF receptor superfamily activation-inducible protein
- CD357 antigen
- GITRtumor necrosis factor receptor superfamily member 18
- Glucocorticoid-induced TNFR-related protein
- tumor necrosis factor receptor superfamily, member 18
GITR, Glucocorticoid-induced TNFR-related gene, is a member of the TNF receptor superfamily, also known as TNFRSF18, and AITR (in humans). It is expressed at low levels on resting T lymphocytes and at high levels on CD4+CD25+ T regulatory (Treg) cells. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF- kappaB activation, and abrogate the inhibitory functions of CD4+CD25+ Treg cells. In vivo activation GITR causes development of autoimmune diseases and restores the suppressed immune responses.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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