GFAP Antibody (4D11)

Images

 
Western Blot: GFAP Antibody (4D11) [NBP1-47782] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GFAP (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ...read more
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] Staining of paraffin-embedded thyroid tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded Adenocarcinoma of colon tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded bladder tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded Carcinoma of kidney tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded Carcinoma of lung tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded Carcinoma of pancreas tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded Carcinoma of thyroid tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded colon tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded endometrium tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded Kidney tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded lung tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded lymph node tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded Ovary tissue using anti-GFAP mouse monoclonal antibody.
Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Staining of paraffin-embedded prostate tissue using anti-GFAPmouse monoclonal antibody.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P
Clone
4D11
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

GFAP Antibody (4D11) Summary

Immunogen
Protein expressed in 293T cell transfected with human GFAP expression vector
Marker
Astrocyte Marker
Specificity
This antibody is specific for Homo sapiens glial fibrillary acidic protein (GFAP), transcript variant 1.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
GFAP
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for GFAP Antibody (4D11)

  • FLJ45472
  • GFAP astrocytes
  • GFAP
  • glial fibrillary acidic protein

Background

This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for GFAP Antibody (NBP1-47782). (Showing 1 - 1 of 1 FAQ).

  1. I am interested in native or recombinant GFAP protein without GST Tag or in urea buffer. Can I use your GFAP antibody (NB100-53809) to detect P0809, P0810 and P1691 GFAP proteins?
    • P0809, P0810 and P1691 are blocking peptides that are not suitable for use with NB100-53809. Unfortunately, we do not carry a GFAP protein without a GST tag. I apologize for the inconvenience.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for GFAP Antibody (NBP1-47782)

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Diseases for GFAP Antibody (NBP1-47782)

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Blogs on GFAP.

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Beta tubulin III, also known as Tuj-1, is a class III member of the beta tubulin protein family. Beta tubulins are one of two structural components that form our microtubule network. While general tubulins play a role in a wide range of cellular pr...  Read full blog post.

The identification of dopaminergic neurons using Tyrosine Hydroxylase in Parkinson's research and LRRK2
Tyrosine hydroxylase (TH) is a crucial enzyme involved in the biosynthesis of dopamine, norepinephrine and epinephrine in the brain.  Specifically, TH catalyzes the conversion of l-tyrosine to l-dihydroxyphenylalanine (l-dopa).  The importance of t...  Read full blog post.

Synapsin I: Implicated in synaptic activity across a diverse range of studies
Synapsins are a family of neuronal proteins that are most renowned for their activity in modulating the pre-synaptic terminal.  Synapsin’s behavior is regulated by protein kinases and phosphatases, which alter the way that synapsin’s i...  Read full blog post.

Glial Fibrillary Acidic Protein (GFAP), The Most Popular Astrocyte Marker
GFAP, a class-III intermediate filament, is a 50kDa protein which is found in the mature and developing astrocytes in the CNS, non-myelinating Schwann cells in the PNS, enteric glial cells (enteric nervous system/ENS), ependymal cells, and radial g...  Read full blog post.

Nestin: Investigating the Link Between New Brain Cells and Depression
Clinical depression (also known as major depressive disorder or MDD) affects many people, but the biological processes that cause it (and are influenced by its treatments) are not well understood. Adult neurogenesis is a newly emerging field that coul...  Read full blog post.

GFAP: Roles in Alzheimer's and Schizophrenia
Glial fibrillary acidic protein (GFAP) is a class III intermediate filament (IF) protein and is used as a marker to distinguish astrocytes from other glial cells during development. GFP may play a role in maintaining mechanical strength and shape in a...  Read full blog post.

Vimentin in Wound Healing
Vimentin is a fundamental 10 nm type III intermediate filament (IF) protein found in many mesenchymal and epithelia tissues, tissue culture cells, and developing neuronal and astrocytic precursor cells of the central nervous system. It frequently co-p...  Read full blog post.

"Whats the Hap" with GFAP?
Glial Fibrillary Acidic Protein (GFAP) is one of the major intermediate filament axonal proteins found in mature astrocytes, the star-shaped glial cells that comprise the majority of cells within the central nervous system (1). Astrocytes perform a wi...  Read full blog post.

GFAP Antibodies are a 'No Brainer' for Neurodegenerative Research
Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature astrocytes, but also an important component of the cytoskeleton in astrocytes during development. Recent developments using GFAP antibodies in astrocyte biology...  Read full blog post.

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Bioinformatics

Gene Symbol GFAP
Entrez