GDNF Partial Recombinant Protein


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Product Details

Applications IA
Please see the vial label for concentration. If unlisted please contact technical services.

Order Details

GDNF Partial Recombinant Protein Summary

A partial protein corresponding to GDNF.
E. coli-expressed amino acids Ser78 - Ile211 (Accession # CAG46721).
Details of Functionality
This recombinant human GDNF has been tested in bioassays by rat C6 cell proliferation. The ED50, calculated by dose-dependent induction of rat C6 cell proliferation, is 1ug/ml, corresponding to a specific activity of 1x10^4units/mg.
Endotoxin Note
Less than 0.01 ng/ug cytokine as determined by the LAL assay.

Packaging, Storage & Formulations

Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid, 10 mM Phosphate buffer, 150 mM NaCl with 1.0% BSA. 0.22 um filtered.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.

Reactivity Notes

This protein was made to the human sequence.


Purity: Greater than 98%, as determined by SDS-PAGE

Alternate Names for GDNF Partial Recombinant Protein

  • Astrocyte-derived trophic factor
  • ATF
  • ATF1
  • ATF2
  • glial cell derived neurotrophic factor
  • glial cell line derived neurotrophic factor
  • glial cell line-derived neurotrophic factor
  • hGDNF
  • HSCR3


Glial Cell derived Neurotrophic Factor (GDNF), a member of the TGF superfamily, is a neurotrophic factor that promotes the survival of various neuronal populations in both the central and peripheral nervous systems during their development. Neuronal subpopulations affected by GDNF include motor neurons, midbrain dopaminergic neurons and Purkinje cells. GDNF is conserved across mammalian species with human and rat orthologs sharing approximately 93% amino acid sequence identity. E. coli-produced recombinant human GDNF is a disulfide-linked, non-glycosylated homodimer composed of two 135 amino acid polypeptides.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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The identification of dopaminergic neurons using Tyrosine Hydroxylase in Parkinson's research and LRRK2
Tyrosine hydroxylase (TH) is a crucial enzyme involved in the biosynthesis of dopamine, norepinephrine and epinephrine in the brain.  Specifically, TH catalyzes the conversion of l-tyrosine to l-dihydroxyphenylalanine (l-dopa).  The importance of t...  Read full blog post.

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Product PDFs


Gene Symbol GDNF

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