Human GDF-15 Biologically Active Protein


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Product Details

Reactivity HuSpecies Glossary
Applications Func, PAGE

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Human GDF-15 Biologically Active Protein Summary

A biologically active protein to GDF15.Source: E. coli
Novus' biologically active proteins are stringently purified to provide only the safest and most highly effective proteins available. This protein was expressed in E. coli, purified by HPLC, QC tested by SDS-PAGE and Western Blot and validated on appropriate cell lines for bioactivity. All HPLC and bioactivity data is provided for your assurance.
Details of Functionality
Data is not available.
Endotoxin Note
Less than 1 EU/ug of the rHuGDF-15 as determined by LAL method.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Reconstitution Instructions
Reconstitute with sterilized 4 mM HCl to a final concentration of 0.1 mg/ml. Stock solutions should be apportioned into working aliquots and stored at -20C. Further dilutions should be made in appropriately buffered solutions.


Theoretical MW
26.2 kDa


This lyophilized preparation is stable at 2-8 degrees C, but should be kept at -20 degrees C for long term storage, preferably desiccated. Upon reconstitution, the preparation is most stable at -20 to -80 degrees C, and can be stored for one week at 2-8 degrees C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degrees C to -80 degrees C. Avoid repeated freeze/thaw cycles.

Alternate Names for Human GDF-15 Biologically Active Protein

  • GDF15
  • growth differentiation factor 15
  • growth/differentiation factor 15
  • Macrophage inhibitory cytokine 1
  • MIC-1
  • MIC-1NSAID-activated gene 1 protein
  • MIC1Prostate differentiation factor
  • NAG-1
  • NAG-1NSAID-regulated gene 1 protein
  • NSAID (nonsteroidal inflammatory drug)-activated protein 1
  • PDF
  • PDFGDF-15
  • PLAB
  • Placental bone morphogenetic protein
  • Placental TGF-beta
  • PTGF-beta
  • PTGFBPTGF-beta


Growth Differentiation Factor 15 (GDF-15) is a divergent member of the TGF-beta superfamily. Biologically active GDF-15 is a disulfide-linked homodimer of the mature protein. Human GDF-15 shares 67% aa sequence identity with rat and mouse GDF-15. GDF-15 is expressed in placenta, brain, kidney, pancreas, prostate, and colon. It inhibits macrophage and platelet activation, regulates angiogenesis, and promotes recovery following myocardial infarction. GDF-15 also promotes cartilage formation, neuronal survival, and appetite suppression.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 2 years from date of receipt.

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Contact Information

Product PDFs


Gene Symbol GDF15

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