GDF-15 Antibody

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Western Blot: GDF-15 Antibody [NBP1-51372] - Analysis of GDF-15 (L64) pAb at 1:500 dilutionLane1:MCF-7 whole cell lysateLane2:Raw264.7 whole cell lysateLane3:PC12 whole cell lysate
Western Blot: GDF-15 Antibody [NBP1-51372] - Analysis of GDF15 (L64) pAb in extracts from HepG2 cells.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51372
    • Availability
      Product Discontinued

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GDF-15 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 32-80 of Human GDF-15.
Specificity
GDF-15 (L64) pAb detects endogenous levels of GDF-15 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
GDF15
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
Application Notes
Western blot (WB) analysis of GDF-15 (L64) pAb in extracts from HepG2 cells.
Theoretical MW
37 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GDF-15 Antibody

  • GDF15
  • GDF-15
  • growth differentiation factor 15
  • growth/differentiation factor 15
  • Macrophage inhibitory cytokine 1
  • MIC-1
  • MIC-1NSAID-activated gene 1 protein
  • MIC1Prostate differentiation factor
  • NAG-1
  • NAG-1NSAID-regulated gene 1 protein
  • NSAID (nonsteroidal inflammatory drug)-activated protein 1
  • PDF
  • PDFGDF-15
  • PLAB
  • PLABNRG-1
  • Placental bone morphogenetic protein
  • Placental TGF-beta
  • PTGF-beta
  • PTGFBPTGF-beta

Background

Growth differentiation factor 15 (GDF-15), also known as PDF, MIC-1, PLAB, NAG-1 or PTGF-beta, is a member of the transforming growth factor beta (TGF beta) superfamily. Synthesized intracellularly, the protein is secreted as a dimer linked by disulfide bonds. Epithelial cells and macrophages are the sites of strongest GDF-15 expression, although it is widely expressed in adult tissue. In the brain, GDF-15 expression occurs in the choroid plexus, from which the protein is secreted into the cerebrospinal fluid. The gene for GDF-15 is responsive to p53 tumor suppressor protein, and in cultured cerebellar granule neurons GDF-15 can prevent cell death by the activation of Akt and inhibition of ERK. GDF-15 acts as a trophic factor for certain classes of neurons, promoting cell survival and differentiation. Overexpression of GDF-15 occurs in prostate cancer and may be a means of diagnosis. In the uterus, GDF-15 may work to suppress maternally derived proinflammatory cytokines, thereby promoting fetal survival.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GDF15
Entrez