GCKR Antibody

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Western Blot: GCKR Antibody [NBP1-51204] - Extracts from NIH-3T3 cells

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51204
    • Availability
      Product Discontinued

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GCKR Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 20-50 of Human GCK.
Specificity
GCK (R43) pAb detects endogenous levels of GCK protein.
Clonality
Polyclonal
Host
Rabbit
Gene
GCKR
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
Application Notes
Western blot (WB) analysis of GCK (R43) pAb in extracts from NIH-3T3 cells
Theoretical MW
55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (approx. pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GCKR Antibody

  • FGQTL5
  • GKRP
  • glucokinase (hexokinase 4) regulator
  • glucokinase (hexokinase 4) regulatory protein
  • Glucokinase regulator
  • glucokinase regulatory protein

Background

Glucokinase (also designated hexokinase IV, HXKIV or GCK) plays a key role in the regulation of glucose-induced insulin secretion. GCK is expressed in pancreatic beta cells where it functions as the major glucose sensor of the body, determining the “set point” for insulin secretion. GCK is also expressed in the liver, where it catalyzes the first committed step in the disposal of glucose. Phosphorylation of glucose by glucokinase appears to be the ratelimiting step for glucose catabolism. A lack of glucokinase activity leads to reduced insulin secretion and hyperglycemia, and has been implicated as a cause for maturity onset diabetes of the youth (MODY). In fact, heterozygous point mutations in the gene encoding GCK have been detected in individuals suffering from MODY.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GCKR