GATA2/3 Antibody

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Immunohistochemistry-Paraffin: GATA2/3 Antibody [NBP1-19391] - Human placenta tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-19391
    • Availability
      Product Discontinued

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GATA2/3 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 270-318 of Human GATA2.
Specificity
GATA2/3 (K304) detects endogenous levels of GATA2/3 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
GATA2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Immunohistochemistry (IHC) analyzes of GATA2/3 (K304) pAb in paraffin-embedded human placenta tissue.

Reactivity Notes

Cross reacts with Human and Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GATA2/3 Antibody

  • endothelial transcription factor GATA-2
  • FLJ45948
  • GATA binding protein 2
  • GATA-binding protein 2NFE1B
  • MGC2306

Background

The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GATA2
Entrez