Galectin-1 Antibody (201002) [Allophycocyanin]

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-61246APC
    • Availability
      Product Discontinued

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Galectin-1 Antibody (201002) [Allophycocyanin] Summary

Immunogen
E. coli-derived recombinant mouse Galectin-1
Ala2-Glu135
Accession # P16045
Specificity
Detects mouse Galectin-1 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human (rh) Galectin-1 is observed, and no cross-reactivity with rhGalectin-2, recombinant mouse (rm) Galectin-3, rmGalectin‑4, rmGalectin‑7, or rhGalectin‑8 is observed.
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
LGALS1
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Alternate Names for Galectin-1 Antibody (201002) [Allophycocyanin]

  • 14 kDa laminin-binding protein
  • 14 kDa lectin
  • Beta-galactoside-binding lectin L-14-I
  • BHL
  • DKFZp686E23103
  • GAL1
  • gal-1
  • Galaptin
  • galectin 1
  • Galectin1
  • Galectin-1
  • GBP
  • HBL
  • HLBP14
  • HPL
  • L-14
  • Lactose-binding lectin 1
  • Lectin galactoside-binding soluble 1
  • lectin, galactoside-binding, soluble, 1
  • LGALS1
  • Putative MAPK-activating protein PM12
  • S-Lac lectin 1

Background

The galectins constitute a large family of carbohydrate-binding proteins with specificity for N-acetyl-lactosamine-containing glycoproteins. At least 14 mammalian galectins, which share structural similarities in their carbohydrate recognition domains (CRD), have been identified to date. The galectins have been classified into the prototype galectins (-1, -2, -5, -7, -10, -11, -13, -14), which contain one CRD and exist either as a monomer or a noncovalent homodimer; the chimera galectins (Galectin-3) containing one CRD linked to a nonlectin domain; and the tandem-repeat galectins (-4, -6, -8, -9, -12) consisting of two CRDs joined by a linker peptide. Galectins lack a classical signal peptide and can be localized to the cytosolic compartments where they have intracellular functions. However, via one or more as yet unidentified non-classical secretory pathways, galectins can also be secreted to function extracellularly. Individual members of the galectin family have different tissue distribution profiles and exhibit subtle differences in their carbohydrate-binding specificities. Each family member may preferentially bind to a unique subset of cell-surface glycoproteins (1-4). Mouse Galectin-1, also known as beta-galactoside-binding lectin L-14-I, lactose-binding lectin 1, S-Lac lectin 1, galaptin and 14 kDa lectin, is a monomeric or homodimeric prototype galectin that is expressed in a variety of cells and tissues including muscle, heart, lymph nodes, spleen, thymus, macrophages, B cells, T cells, dendritic cells, and tumor cells. It preferentially binds laminin, fibronectin, 90K/Mac-2BP, CD45, CD43, CD7, CD2, CD3, and ganglioside GM1. Galectin-1 modulates cell growth, proliferation and differentiation, either positively or negatively, depending on the cell type and activation status. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes. It modulates cytokine secretion by inducing Th2 type cytokines and inhibiting pro-inflammatory cytokine production. Galectin-1 can also modulate cell-cell as well as cell-matrix interactions and depending on the cell type and developmental stage, promote cell attachment or detachment. Galectin-1 has immunosuppressive and anti-inflammatory properties and has been shown to suppress acute and chronic inflammation and autoimmunity. Mouse and human Galectin-1 share about 88% amino acid sequence similarity (1-5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol LGALS1
Entrez