GADD153/CHOP Antibody

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Immunohistochemistry-Paraffin: CHOP/GADD153 Antibody [NBP1-35898] - Human breast carcinoma

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-35898
    • Availability
      Product Discontinued

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GADD153/CHOP Antibody Summary

Immunogen
Recombinant human full length GADD153 protein.
Marker
ER Stress Marker
Specificity
This product is specific for GADD153
Clonality
Polyclonal
Host
Rabbit
Gene
DDIT3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50

Reactivity Notes

This product is specific for Human.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
10mM PBS (pH 7.4) and 1.0% BSA
Preservative
0.1% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for GADD153/CHOP Antibody

  • C/EBP-homologous protein 10
  • C/EBP-homologous protein
  • CCAAT/enhancer-binding protein homologous protein
  • CEBP zeta
  • CHOP
  • CHOP10 CEBPZ
  • CHOP10
  • CHOP-10
  • CHOPC/EBP zeta
  • DDIT3
  • DDIT-3
  • DNA damage-inducible transcript 3 protein
  • DNA-damage-inducible transcript 3
  • GADD153
  • Growth arrest and DNA damage-inducible protein GADD153

Background

CHOP (also known as growth arrest and DNA-damage-inducible protein GADD153) is a 27 kD member of the C/EBP transcription factor family containing a basic region involved in DNA binding and a leucine zipper domain. This nuclear protein functions as a dimer to inhibit the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA target sequences. CHOP (GADD153) is induced by endoplasmic-reticulum stress and nutrient deprivation. Phosphorylation by p38-MAP kinase enhances activity of this protein while CK2 phosphorylation decreases activity. CHOP (GADD153) has been shown to interact with c-jun, c-fos, C/EBP, and LAP. The Poly6122 antibody has been shown to be useful for Western blotting of the human CHOP protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Additional GADD153/CHOP Products

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PTMs for CHOP/GADD153 Antibody (NBP1-35898)

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Bioinformatics

Gene Symbol DDIT3
Entrez