GAB1 [p Tyr627] Antibody



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GAB1 [p Tyr627] Antibody Summary

Synthetic phosphopeptide derived from human Gab 1 around the phosphorylation site of Tyrosine 627.
p Tyr627
Detects endogenous levels of Gab 1 protein only when phosphorylated at Y627.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Phosphate buffered saline (PBS) approx. pH 7.2.
0.05% Sodium Azide
1.0 mg/ml
Immunogen affinity purified


Application Notes
Western blot (WB) analyzes of p-Gab 1 (Y627) pAb in extracts from HuvEc EGF cells.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
110 kDa

Reactivity Notes

Human, Mouse


The insulin receptor substrate (IRS) family of proteins mediate a variety of intracellular signaling pathways by serving as signaling platforms downstream of several receptor tyrosine kinases, including the insulin and insulinlike growth factor (IGF-1) receptors. Gab 1 (GRB2-associated binder 1), one such member of the IRS family, plays an important role in cellular growth response, transformation and apoptosis. Gab 1 is a multi-substrate docking protein that functions downstream in the signaling pathways of different receptor kinases, including EGFR. Gab1 is tyrosine phosphorylated normally in response to insulin and consequently enhances phosphatidylinositol 3- kinase (PI3K) binding. In response to osmotic shock, tyrosine-phosphorylated Gab 1 (p-Gab 1) also binds and activates phosphatidylinositol 3-kinase, suggesting that Gab 1 is the major site for PI3K recruitment following osmotic shock stimulation.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol GAB1

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