GAB1 [p Tyr627] Antibody

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Western Blot: GAB1 [p Tyr627] Antibody [NBP1-51472] - p-Gab 1 (Y627) pAb in extracts from HuvEc EGF cells.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51472
    • Availability
      Product Discontinued

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GAB1 [p Tyr627] Antibody Summary

Immunogen
Synthetic phosphopeptide derived from human Gab 1 around the phosphorylation site of Tyrosine 627.
Modification
p Tyr627
Specificity
Detects endogenous levels of Gab 1 protein only when phosphorylated at Y627.
Clonality
Polyclonal
Host
Rabbit
Gene
GAB1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:500- 1:1000
Application Notes
Western blot (WB) analyzes of p-Gab 1 (Y627) pAb in extracts from HuvEc EGF cells.
Theoretical MW
110 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GAB1 [p Tyr627] Antibody

  • GRB2-associated binder 1
  • GRB2-associated binding protein 1
  • GRB2-associated-binding protein 1
  • Growth factor receptor bound protein 2-associated protein 1

Background

The insulin receptor substrate (IRS) family of proteins mediate a variety of intracellular signaling pathways by serving as signaling platforms downstream of several receptor tyrosine kinases, including the insulin and insulinlike growth factor (IGF-1) receptors. Gab 1 (GRB2-associated binder 1), one such member of the IRS family, plays an important role in cellular growth response, transformation and apoptosis. Gab 1 is a multi-substrate docking protein that functions downstream in the signaling pathways of different receptor kinases, including EGFR. Gab1 is tyrosine phosphorylated normally in response to insulin and consequently enhances phosphatidylinositol 3- kinase (PI3K) binding. In response to osmotic shock, tyrosine-phosphorylated Gab 1 (p-Gab 1) also binds and activates phosphatidylinositol 3-kinase, suggesting that Gab 1 is the major site for PI3K recruitment following osmotic shock stimulation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GAB1