GAB1 Antibody


Western Blot: GAB1 Antibody [NBP1-19891] Extracts from raw264.7 cells.
Western Blot: GAB1 Antibody [NBP1-19891] - extracts from HuvEc cells.

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GAB1 Antibody Summary

Synthetic peptide, corresponding to amino acids 590-641 of Human Gab1.
Immunogen affinity purified
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  • Western Blot 1:500- 1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
Application Notes
Western blot (WB) analyzes of Gab1 (G621) pAb in extracts from raw264.7 cells.
Theoretical MW
76 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross reacts with Human and Mouse.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2)
15mM Sodium Azide
1.0 mg/ml
Immunogen affinity purified

Alternate Names for GAB1 Antibody

  • GRB2-associated binder 1
  • GRB2-associated binding protein 1
  • GRB2-associated-binding protein 1
  • Growth factor receptor bound protein 2-associated protein 1


Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter protein such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families,IRS-1 serves primarily as the major insulin receptor substrate. Shc and Gab 1 also participate in insulin signaling by linking the insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. Gab 1 is also thought to be involved in the EGF receptor signaling pathway.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Gene Symbol GAB1