GAB1 Antibody

Images

 
Western Blot: GAB1 Antibody [NBP1-19891] Extracts from raw264.7 cells.
Western Blot: GAB1 Antibody [NBP1-19891] - extracts from HuvEc cells.

Product Details

Summary
Product Discontinued
View other related GAB1 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-19891
    • Availability
      Product Discontinued

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GAB1 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 590-641 of Human Gab1.
Clonality
Polyclonal
Host
Rabbit
Gene
GAB1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500- 1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
Application Notes
Western blot (WB) analyzes of Gab1 (G621) pAb in extracts from raw264.7 cells.
Theoretical MW
76 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross reacts with Human and Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GAB1 Antibody

  • GRB2-associated binder 1
  • GRB2-associated binding protein 1
  • GRB2-associated-binding protein 1
  • Growth factor receptor bound protein 2-associated protein 1

Background

Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter protein such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families,IRS-1 serves primarily as the major insulin receptor substrate. Shc and Gab 1 also participate in insulin signaling by linking the insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. Gab 1 is also thought to be involved in the EGF receptor signaling pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for GAB1 Antibody (NBP1-19891) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for GAB1 Antibody (NBP1-19891)

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Research Areas for GAB1 Antibody (NBP1-19891)

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Blogs on GAB1.

CD19: An Undoubted Biomarker for B Cells
CD19 is a cell surface protein member of the large immunoglobulin superfamily that complexes with CD21, CD81, and CD225 in the membrane of mature B-cells. A major function of CD19 is to assemble with the antigen receptor of B-lymphocytes to decrease t...  Read full blog post.

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Bioinformatics

Gene Symbol GAB1
Entrez