FMRP Antibody

Images

 
Immunohistochemistry-Paraffin: FMRP Antibody [NBP1-52522] - Analysis of anti-FMR1 antibody with human brain, cortex at concentration 2.5 ug/ml.
Immunohistochemistry-Paraffin: FMRP Antibody [NBP1-52522] - Analysis of anti-FMR1 antibody with human placenta at concentration 2.5 ug/ml.

Product Details

Summary
Product Discontinued
View other related FMRP Primary Antibodies

Order Details


    • Catalog Number
      NBP1-52522
    • Availability
      Product Discontinued

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FMRP Antibody Summary

Immunogen
Synthetic peptide C-NPNKPATKDTFHKIK from an internal region of human FMR1 (NP_002015.1).
Specificity
Human FMR1.
Predicted Species
Turkey (100%), Opossum (100%), Bovine (93%). Backed by our 100% Guarantee.
Clonality
Polyclonal
Host
Goat
Gene
FMR1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 0.3 - 1 ug/ml
  • ELISA 1:32000
  • Immunohistochemistry-Paraffin 2.5 ug/ml
Application Notes
WB: Approx. 70Da band observed in lysates of cell lines HeLa and Jurkat (calculated MW of 71.2kDa according to NP_002015.1).

Reactivity Notes

Gorilla, Orangutan, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Elephant (100%), Panda (100%), Platypus (100%), Xenopus (80%).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
TBS (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for FMRP Antibody

  • FMRPFRAXAPOF
  • fragile X mental retardation 1 protein
  • fragile X mental retardation 1
  • MGC87458
  • POF1
  • premature ovarian failure 1
  • Protein FMR-1

Background

Fragile X syndrome is the most common inherited form of mental retardation. It is caused by loss of FMR1 gene activity due to either lack of expression or expression of a mutant form of the protein. In mammals, FMR1 is a member of a small protein family that consists of FMR1, FXR1, and FXR2. All three members bind RNA and contain sequence motifs that are commonly found in RNA-binding proteins, including two KH domains and an RGG box.The Drosophila genome contains a single gene homologous to the FXR family. dFMR1 is subjected to transcriptional and posttranscriptional regulation during development and it homomerizes, like its human counterpart. dFMR1 profile of expression recapitulates that of the human FXR protein family: it is highly enriched in muscles, in central nervous system and in gonads. In the larval brain, anti-dFMR1 also recognizes mushroom bodies, a centre that mediates learning and memory. These features make the fly an ideal system to analyze the role of the FXR family and to identify genes in the FMRP pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for FMRP Antibody (NBP1-52522)

Discover related pathways, diseases and genes to FMRP Antibody (NBP1-52522). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for FMRP Antibody (NBP1-52522)

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Bioinformatics

Gene Symbol FMR1
Entrez
Uniprot