Recombinant Flt-3 Ligand Protein Summary
A partial protein corresponding to FLT3LG.
Insect cell expressed N-terminal His-Tagged amino acids Thr 27-Pro 185 of hFLT-3L (accession #NM_001459).
|Details of Functionality
This recombinant human Flt3 Ligand has been tested in a THP-1 cell proliferation assay with an observed ED50 of 0.4 ng/ml, corresponding to a specific activity of approximately 2.5x10^6 Units/mg.
| Protein/Peptide Type
Partial Recombinant Protein
Less than 0.1 ng/ug cytokine as determined by the LAL assay.
This protein was made to the human sequence.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid; 10 mM NaH2PO4, 0.15M NaCl, pH 7.2, 0.22 um filtered.
0.09% Sodium Azide
Purity: Greater than 98%, as determined by SDS-PAGE
Alternate Names for Recombinant Flt-3 Ligand Protein
- Flt3 ligand
- Flt-3 Ligand
- fms-related tyrosine kinase 3 ligand
- SL cytokine
Flt3 (or FMS-related tyrosine kinase 3) Ligand, also known as Flk2 Ligand, is a growth factor that regulates proliferation of early hematopoietic cells. Flt3 Ligand binds to cells expressing the tyrosine kinase receptor Flt3. By itself, Flt3 Ligand does not stimulate proliferation of early hematopoietic cells. Instead, it synergizes with other colony-stimulating factors (CSFs) and interleukins to induce growth and differentiation. Unlike CSFs, however, Flt3 Ligand exerts no activity on mast cells. Multiple isoforms of Flt3 Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Human Flt3 Ligand shares 71% and 65% amino acid sequence identity with mouse and rat Flt3 Ligand, respectively. Human and mouse Flt3 Ligand show cross-species activity. Recombinant human Flt3 Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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