Recombinant Flt-3 Ligand Protein

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Summary
Product Discontinued
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    • Catalog Number
      NBP1-42883
    • Availability
      Product Discontinued

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Recombinant Flt-3 Ligand Protein Summary

Description
A partial protein corresponding to FLT3LG.
Preparation
Method
Insect cell expressed N-terminal His-Tagged amino acids Thr 27-Pro 185 of hFLT-3L (accession #NM_001459).
Details of Functionality
This recombinant human Flt3 Ligand has been tested in a THP-1 cell proliferation assay with an observed ED50 of 0.4 ng/ml, corresponding to a specific activity of approximately 2.5x10^6 Units/mg.
Protein/Peptide Type
Partial Recombinant Protein
Gene
FLT3LG
Endotoxin Note
Less than 0.1 ng/ug cytokine as determined by the LAL assay.

Reactivity Notes

This protein was made to the human sequence.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Sterile liquid; 10 mM NaH2PO4, 0.15M NaCl, pH 7.2, 0.22 um filtered.
Preservative
0.09% Sodium Azide

Notes

Purity: Greater than 98%, as determined by SDS-PAGE

Alternate Names for Recombinant Flt-3 Ligand Protein

  • FL
  • Flt3 ligand
  • Flt-3 Ligand
  • Flt3L
  • FLT3LG
  • fms-related tyrosine kinase 3 ligand
  • SL cytokine

Background

Flt3 (or FMS-related tyrosine kinase 3) Ligand, also known as Flk2 Ligand, is a growth factor that regulates proliferation of early hematopoietic cells. Flt3 Ligand binds to cells expressing the tyrosine kinase receptor Flt3. By itself, Flt3 Ligand does not stimulate proliferation of early hematopoietic cells. Instead, it synergizes with other colony-stimulating factors (CSFs) and interleukins to induce growth and differentiation. Unlike CSFs, however, Flt3 Ligand exerts no activity on mast cells. Multiple isoforms of Flt3 Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Human Flt3 Ligand shares 71% and 65% amino acid sequence identity with mouse and rat Flt3 Ligand, respectively. Human and mouse Flt3 Ligand show cross-species activity. Recombinant human Flt3 Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol FLT3LG
Entrez