Flamingo homolog 1/CELSR3 Antibody (763103) [Alexa Fluor® 750]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
763103
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 750
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Flamingo homolog 1/CELSR3 Antibody (763103) [Alexa Fluor® 750] Summary

Immunogen
E. coli-derived recombinant human CELSR3
Val531-Ser711
Accession # Q9NYQ7
Specificity
Detects human CELSR3 in ELISA.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
CELSR3
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
0.09% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Flamingo homolog 1/CELSR3 Antibody (763103) [Alexa Fluor® 750]

  • Cadherin family member 11
  • cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
  • CDHF11
  • CDHF11RESDA1
  • CELSR3
  • EGFL1
  • EGFL1cadherin EGF LAG seven-pass G-type receptor 3
  • EGF-like protein 1
  • EGF-like-domain, multiple 1
  • epidermal growth factor-like 1
  • Epidermal growth factor-like protein 1
  • Flamingo homolog 1
  • FMI1anchor protein
  • HFMI1
  • KIAA0812
  • MEGF2
  • MEGF2cadherin EGF LAG seven-pass G-type receptor 3, flamingo (Drosophila) homolog
  • multiple EGF-like domains 2
  • Multiple EGF-like domains protein 2
  • Multiple epidermal growth factor-like domains protein 2
  • RESDA1

Background

CELSR3 (Cadherin EGF LAG Seven-pass G-type Receptor 3; also cadherin family member 11/CDHF11, FMI1 and EGFL1) is a 355 kDa (predicted) member of the LN-7TM subfamily, GPCR 2 family of proteins. It is coexpressed with Fzd3 on postmigratory neurons of the developing DRG and cranial ganglia, and appears to serve as an axonal guidance cue. Mature human CELSR3 is 3280 amino acids (aa) in length (aa 33-3312). It is a highly complex 7-transmembrane protein that contains a 2508 aa extended N-terminal extracellular region (aa 33-2540) plus a 538 aa C-terminal cytoplasmic domain. The N-terminal region contains nine consecutive cadherin domains (aa 326-1265), followed by a mixture of eight EGF-like and three laminin-like domains, and one membrane-proximal GPS domain. There are two potential isoform variants. One shows a five aa insertion after Gly2158, while another possesses an alternative start site at Met276. Over aa 531-711, human CELSR3 shares 98% aa sequence identity with mouse CELSR3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CELSR3
Entrez
Uniprot