FKBP52/FKBP4 Antibody

Images

 
Western Blot: FKBP52/FKBP4 Antibody [NB100-68238] - Detection of Human and Mouse FKBP4/FKBP52 by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-68238
    • Availability
      Product Discontinued

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FKBP52/FKBP4 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 440 and 459 human FK506 binding protein 4 using the numbering given in entry NP_002005.1 (GeneID 2288).
Clonality
Polyclonal
Host
Rabbit
Gene
FKBP4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000 - 1:10000
  • Immunocytochemistry/Immunofluorescence 1:100 to 1:1000
  • Immunohistochemistry 1:200 to 1:1000
  • Immunohistochemistry-Paraffin 1:200 to 1:1000
Application Notes
This antibody is not recommended for Western Blot analysis. Epitope retrieval with citrate buffer pH6.0 is recommended for staining Paraffin tissue sections
Positive Control
FKBP4/FKBP52 Lysate (NBL1-10738)
Publications
Read Publication using NB100-68238.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
TBS and 0.1% BSA
Preservative
0.09% Sodium Azide
Concentration
0.2 mg/ml
Purity
Immunogen affinity purified

Alternate Names for FKBP52/FKBP4 Antibody

  • 51 kDa FK506-binding protein
  • 52 kDa FKBP
  • 59 kDa immunophilin
  • EC 5.2.1.8
  • FK506 binding protein 4, 59kDa
  • FK506-binding protein 4 (59kD)
  • FK506-binding protein 4
  • FKBP4
  • FKBP-4
  • FKBP51
  • FKBP52
  • FKBP-52
  • FKBP52T-cell FK506-binding protein, 59kD
  • FKBP59
  • FKBP5952 kDa FK506-binding protein
  • HBI
  • HSP binding immunophilin
  • Hsp56
  • HSP-binding immunophilin
  • Immunophilin FKBP52
  • p52
  • p59
  • peptidyl-prolyl cis-trans isomerase FKBP4
  • peptidylprolyl cis-trans isomerase
  • PPIase FKBP4
  • PPIase
  • rotamase

Background

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for FKBP4/FKBP52 Antibody (NB100-68238)(1)

We have publications tested in 1 confirmed species: Human.


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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol FKBP4
Entrez
Uniprot