Fibrinogen Antibody (MFB-HB)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-50102
    • Availability
      Product Discontinued

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Fibrinogen Antibody (MFB-HB) Summary

Immunogen
The antibody reacts specifically with fibrin of human and canine origin.
Specificity
The antibody reacts specifically with fibrin of human and canine origin. It binds with moderate affinity to human fibrinogen, but does not react with other human plasma proteins.
Isotype
IgM
Clonality
Monoclonal
Host
Mouse
Gene
FGA
Purity
Unpurified
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Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
The antibody is useful for staining sections by immunohistochemistry or immunofluo­rescence. It reveals early and aged fibrinous depositions. The antibody can be used for ELISA determina­tion of fibrin related products in biological fluids. It can easily be conjugated to peroxidase, FITC and TRITC.The antibody can be used for immunohistology on acetone or ethanol fixed cryostat sections. It has to be diluted 1:30 - 1:50, preferably in phosphate buffered saline. Start diluting for ELISA at 1:1000.

Reactivity Notes

Human, Canine

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Ascites
Preservative
0.1% Sodium Azide
Purity
Unpurified

Alternate Names for Fibrinogen Antibody (MFB-HB)

  • Factor I
  • FGA
  • FGB
  • Fib2
  • fibrinogen alpha chain
  • Fibrinogen
  • fibrinogen, A alpha polypeptide
  • MGC119422
  • MGC119423
  • MGC119425

Background

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol FGA
Entrez