Fibrinogen Antibody (41D9)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB120-10069
    • Availability
      Product Discontinued

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Fibrinogen Antibody (41D9) Summary

Immunogen
Fibrin degradation products.
Localization
Secreted
Specificity
Fibrinogen, Fibrin degradation products.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
FGA
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
Application Notes
ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Can be used under both reducing and non-reducing conditions.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.

Reactivity Notes

Cross-reacts with Human.Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Purity
Protein A purified

Alternate Names for Fibrinogen Antibody (41D9)

  • Factor I
  • FGA
  • FGB
  • Fib2
  • fibrinogen alpha chain
  • Fibrinogen
  • fibrinogen, A alpha polypeptide
  • MGC119422
  • MGC119423
  • MGC119425

Background

Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol FGA
Entrez