Fibrinogen Antibody (15H12)



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Fibrinogen Antibody (15H12) Summary

Fibrin degradation products.
Fibrinogen, Fibrin degradation products.
Protein A purified
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  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Sandwich ELISA 1:100-1:2000
Application Notes
WB: Use at an assay dependent dilution. Detects fibrinogen in Western blotting after electrophoresis under both reducing and non-reducing conditions. Not tested in other applications. *Optimal dilutions/concentrations should be determined by the end user.

Reactivity Notes

Not yet tested in other species.

Packaging, Storage & Formulations

Store at 4C. Do not freeze.
PBS (pH 7.4)
0.09% Sodium Azide
Protein A purified

Alternate Names for Fibrinogen Antibody (15H12)

  • Factor I
  • FGA
  • FGB
  • Fib2
  • fibrinogen alpha chain
  • Fibrinogen
  • fibrinogen, A alpha polypeptide
  • MGC119422
  • MGC119423
  • MGC119425


Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1-16 amino acids) and B (1-17 amino acids) are released by thrombin from the N-terminal parts of alpha- and beta-chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Fibrinogen Antibody (NB200-419). (Showing 1 - 1 of 1 FAQ).

  1. Could you tell me what part of fibrinogen is recognised under reducing conditions - a, b, or g chains?
    • The inventor told that this antibody has not been tested against the alpha, beta or gamma chains specifically, however, it recognizes conformational epitopes on human fibrinogen and fibrin degradation products. This hybridoma clone was from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with fibrin degradation products.

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Isotype Controls

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Gene Symbol FGA