FGF R4 Antibody (4H2B10B2) Summary
Recombinant human FGFR4.
Ni-NTA purified truncated recombinant FGFR4-Trx-His expressed in E. Coli strain BL21 (DE3)
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- Western Blot 1:500-1:2000
- ELISA 1:10000
- Immunohistochemistry-Frozen 1:10-1:500
- Immunohistochemistry-Paraffin 1:200
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.03% Sodium Azide
This product is unpurified. The exact concentration of antibody is not quantifiable.
Alternate Names for FGF R4 Antibody (4H2B10B2)
- CD334 antigen
- EC 2.7.10
- EC 22.214.171.124
- FGF R4
- fibroblast growth factor receptor 4
- JTK2hydroxyaryl-protein kinase
- protein-tyrosine kinase
- tyrosine kinase related to fibroblast growth factor receptor
- tyrosylprotein kinase
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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