FGF R4 Antibody (4H2B10B2)

Images

 
Western Blot: FGF R4 Antibody (4H2B10B2) [NBP1-50541] - Analysis of anti-FGFR4 antibody with truncated FGFR4-Trx-His recombinant protein.
Immunohistochemistry-Paraffin: FGF R4 Antibody (4H2B10B2) [NBP1-50541] - Analysis of anti-FGFR4 antibody with human liver at dilution 1:200.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC-Fr, IHC-P
Clone
4H2B10B2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
This product is unpurified. The exact concentration of antibody is not quantifiable.

Order Details

FGF R4 Antibody (4H2B10B2) Summary

Immunogen
Recombinant human FGFR4.
Specificity
Ni-NTA purified truncated recombinant FGFR4-Trx-His expressed in E. Coli strain BL21 (DE3)
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FGFR4
Purity
Unpurified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:2000
  • ELISA 1:10000
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:200

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Ascites
Preservative
0.03% Sodium Azide
Concentration
This product is unpurified. The exact concentration of antibody is not quantifiable.
Purity
Unpurified

Alternate Names for FGF R4 Antibody (4H2B10B2)

  • CD334 antigen
  • CD334
  • EC 2.7.10
  • EC 2.7.10.1
  • FGF R4
  • FGFR4
  • FGFR-4
  • fibroblast growth factor receptor 4
  • JTK2hydroxyaryl-protein kinase
  • MGC20292
  • protein-tyrosine kinase
  • TKF
  • tyrosine kinase related to fibroblast growth factor receptor
  • tyrosylprotein kinase

Background

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol FGFR4
Entrez
Uniprot