Recombinant Human FGF R2 alpha (IIIc), Fc Protein Summary
A disulfide-linked homodimeric protein corresponding to Arg22 - Glu377 & Leu27 - Glu377 (N-terminal Human FGF R2 alpha IIIc #P21802), IEGRMD, and Pro100 - LYs330 (C-terminal Human IgG1) of FGF R2 alpha.
Source: Mouse myeloma cell line, NS0-derived
Lyophilized from a 0.2 um filtered solution in PBS.
|Details of Functionality
Measured by its ability to inhibit FGF acidic dependent proliferation of NR6R-3T3 mouse fibroblast cells. The ED50 for this effect is typically 0.5-2 ng/mL.
| Protein/Peptide Type
<0.10 EU per 1 ug of the protein by the LAL method.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Reconstitute with 0.1 mg/ml in sterilized PBS to desired concentration.
This product is provided in a Carrier Free format and does NOT contain BSA. This lyophilized preparation is stable at 2-8 degrees C, but should be kept at -20 degrees C for long term storage, preferably desiccated. Upon reconstitution, the preparation is most stable at -20 to -80 degrees C, and can be stored for one week at 2-8 degrees C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degrees C to -80 degrees C. Avoid repeated freeze/thaw cycles.
Alternate Names for Recombinant Human FGF R2 alpha (IIIc), Fc Protein
Fibroblast growth factors (FGFs) are members of a large family of structurally related polypeptides that are potent physiological regulators of growth and differentiation for a wide variety of cells of mesodermal, ectodermal and endodermal origin. Four genes encoding for high affinity cell surface FGF receptors (FGFRs) have been identified: FGFR1, FGFR2, FGFR3 and FGFR4. FGFRs are members of the tyrosine kinase family of growth factor receptors. FGFR2 is highly expressed in developing human tissues including the brain, choroids plexus, lung etc.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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