FGD1 Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB300-852
    • Availability
      Product Discontinued

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FGD1 Antibody Summary

Immunogen
Synthetic peptide C-TAEPPESPQTRDKT, representing the C-Terminus of the human protein according to NP_004454.2.
Specificity
FGD1
Clonality
Polyclonal
Host
Goat
Gene
FGD1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Peptide ELISA 1:2000
Application Notes
This antibody can be used for ELISA and Western Blot. In Western Blot preliminary experiments gave approx 50kDa and 60kDa bands in Human Muscle lysates. These bands were successfully blocked by incubation with the immunising peptide. Please note that currently we cannot find an explanation in the literature for the bands we observe given the predicted size of approx. 110kDda according to NP_004454. Not tested in other applications. Recommended Starting Dilution:* ELISA (peptide): 1:1,000 WB: 1ug/ml *Optimal dilutions should be determined by the end user.

Reactivity Notes

Tested: Expected from sequence similarity: Human

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
Tris (pH 7.3), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for FGD1 Antibody

  • faciogenital dysplasia (Aarskog-ScRhoGEF and PH domain-containing protein 1
  • Faciogenital dysplasia 1 protein
  • FGDYMRXS16
  • FYVE, RhoGEF and PH domain containing 1
  • Rho/Rac guanine nucleotide exchange factor FGD1
  • ZFYVE3AAS
  • Zinc finger FYVE domain-containing protein 3

Background

FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol FGD1
Entrez
Uniprot