Fes Antibody

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Immunohistochemistry-Paraffin: FES Antibody [NBP1-19673] - Paraffin-embedded human liver carcinoma tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-19673
    • Availability
      Product Discontinued

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Fes Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 131-180 of Human Fes.
Clonality
Polyclonal
Host
Rabbit
Gene
FES
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of Fes (K161) pAb in extracts from HUVEC serum 20% 30'.
Immunohistochemistry (IHC) analyzes of Fes (K161) pAb in paraffin-embedded human liver carcinoma tissue.
Theoretical MW
80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Fes Antibody

  • EC 2.7.10
  • EC 2.7.10.2
  • feline sarcoma oncogene
  • feline sarcoma virus
  • Fes
  • FPS
  • Proto-oncogene c-Fes
  • Proto-oncogene c-Fps
  • proto-oncogene tyrosine-protein kinase Fes/Fps
  • tyrosine-protein kinase Fes/Fps

Background

FES is a protooncogene that encodes a protein-tyrosine kinase distinct from c-Src, c-Abl and other nonreceptor tyrosine kinases. FES was originally identified as the cellular homolog of several transforming retroviral oncoproteins. FES plays a role in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell-cell interaction. Genetic analysis using transgenic mouse model implicate FES in the regulation of inflammation and innate immunity. FES modulates the innate immune response of macrophages to LPS challenge, in part, by regulating the internalization and down-regulation of the TLR4 receptor complex.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics Tool for Fes Antibody (NBP1-19673)

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Bioinformatics

Gene Symbol FES
Entrez