Fc gamma RI/CD64 Antibody (276426) [Fluorescein]

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Human peripheral blood monocytes were stained with Mouse Anti-Human Fc gamma RI/CD64 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB12571F, filled histogram) or isotype control antibody (Catalog # IC002F, ...read more

Product Details

Summary
Product Discontinued
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    • Catalog Number
      FAB12571F
    • Availability
      Product Discontinued

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Fc gamma RI/CD64 Antibody (276426) [Fluorescein] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Fc gamma  RI/CD64
Gln16-Pro288
Accession # P12314.2
Specificity
Detects human Fc gamma RI/CD64 in direct ELISAs and Western blots. In Western blots, this antibody does not cross-react with recombinant mouse (rm) Fc gamma  RI, rmFc gamma  RII, recombinant human (rh) Fc gamma  RIIA, rhFc gamma  RIIB, or rhFc gamma  RIIIB.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FCGR1A
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
Publications
Read Publication using
FAB12571F in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Fc gamma RI/CD64 Antibody (276426) [Fluorescein]

  • CD64 antigen
  • CD64
  • Fc fragment of IgG, high affinity Ia, receptor (CD64)
  • Fc gamma RI
  • FCG1
  • Fc-gamma receptor I B2
  • Fc-gamma RI
  • Fc-gamma RIA
  • FcgammaRIa
  • FCGR1
  • FcgRI
  • FCRI
  • FLJ18345
  • high affinity Ia, receptor for (CD64)
  • high affinity immunoglobulin gamma Fc receptor I
  • IgG Fc receptor I

Background

Receptors for the Fc region of IgG (Fc gamma Rs) are members of the Ig superfamily that function in the activation or inhibition of immune responses such as degranulation, phagocytosis, ADCC (antibody-dependent cellular toxicity), cytokine release, and B cell proliferation (1-3). The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma  RI (also known as CD64), Fc gamma  RII (CD32), and Fc gamma  RIII (CD16). Each group may be encoded by multiple genes and exist in multiple isoforms depending on species and cell type. The CD64 proteins are high affinity receptors (~10‑8 - 10-9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins are lower affinity receptors (~10-6 - 10-7 M) that only recognize IgG aggregates surrounding multivalent antigens (1, 4). Fc gamma Rs that deliver an activating signal either have an intrinsic immunoreceptor tyrosine-based activation motif (ITAM) within their cytoplasmic domains or associate with one of the ITAM-bearing adapter subunits, Fc R gamma or zeta (3, 5). The only inhibitory member in human and mouse, Fc gamma  RIIb, has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). The coordinated functioning of activating and inhibitory receptors is necessary for successful initiation, amplification, and termination of immune responses (5).

Three highly homologous genes (A, B, and C) sharing 98% identity at the nucleotide level have been identified for the human CD64 group (1). Fc gamma RI is transmembrane protein with three extracellular Ig-like domains, and it delivers an activating signal via the associated Fc R gamma accessory chain. The genes for Fc gamma  RIB and Fc gamma  RIC contain stop codons within their membrane proximal Ig-like domains, indicating possible secreted receptors (1, 6). An mRNA splice variant of Fc gamma RIB has a deletion of the membrane-proximal Ig-like domain and encodes a putative transmembrane receptor (6). The high affinity recognition of IgG by Fc gamma RI permits the triggering of effector responses at low IgG concentrations typical of early immune responses (2). Fc gamma RI is expressed constitutively on monocytes and macrophages and can be induced on neutrophils and eosinophils (1, 4). Its expression is up-regulated during bacterial infections and sepsis. Over amino acids (aa) 16-288, human and mouse share 72% aa sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAB12571F
Species: Hu
Applications: Flow

Publications for Fc gamma RI/CD64 Antibody (FAB12571F)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow.


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Bioinformatics

Gene Symbol FCGR1A
Entrez
Uniprot