Fas/TNFRSF6/CD95 Antibody Summary
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human EP1. The exact sequence is proprietary.
Isoform 1: Cell membrane; Single-pass type I membrane protein; Isoform 2: Secreted; Isoform 3: Secreted; Isoform 4: Secreted; Isoform 5: Secreted; Isoform 6: Secreted;
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Western Blot 1:500-1:3000
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
Immunogen affinity purified
Alternate Names for Fas/TNFRSF6/CD95 Antibody
- Apo-1 antigen
- apoptosis antigen 1
- Apoptosis-mediating surface antigen FAS
- CD95 antigen
- Fas (TNF receptor superfamily, member 6)
- Fas AMA
- Fas antigen
- FASLG receptor
- TNFRSF6member 6
- tumor necrosis factor receptor superfamily member 6
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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