Fas/TNFRSF6/CD95 Antibody (LT95) [Allophycocyanin]

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Flow Cytometry: Fas/TNFRSF6/CD95 Antibody (LT95) [Allophycocyanin] [NBP1-50074] - Surface staining of human peripheral blood cells with anti-CD95 (LT95) APC.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-50074
    • Availability
      Product Discontinued

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Fas/TNFRSF6/CD95 Antibody (LT95) [Allophycocyanin] Summary

Immunogen
HUT-78 human T cell lymphoma cell line
Localization
Type I membrane protein (isoform 1); Secreted (isoforms 2 to 6).
Specificity
The antibody LT95 reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FAS
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 10 ul/100 ul of whole blood or 10^6 cells in suspension
Application Notes
Flow Cytometry Use at an assay dependant concentration. Does not induce Fas mediated apoptosis in susceptible cells. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS and 0.2% (w/v) high grade BSA (protease free)
Preservative
15mM Sodium Azide
Purity
Protein A purified

Notes

Store in the dark. Avoid prolonged exposure to light.

Alternate Names for Fas/TNFRSF6/CD95 Antibody (LT95) [Allophycocyanin]

  • Apo-1 antigen
  • Apo-1
  • apoptosis antigen 1
  • Apoptosis-mediating surface antigen FAS
  • APT1
  • APT1FASTM
  • CD95 antigen
  • CD95
  • CD95ALPS1A
  • Fas (TNF receptor superfamily, member 6)
  • Fas AMA
  • Fas antigen
  • Fas
  • FAS1
  • FASLG receptor
  • TNFRSF6
  • TNFRSF6member 6
  • tumor necrosis factor receptor superfamily member 6

Background

CD178 is a 38-42 kD type II glycoprotein also known as Fas ligand and CD95L. CD178 belongs to the TNF superfamily and is expressed on activated T lymphocytes, NK cells, monocytes, and granulocytes. CD178 is also expressed on parenchymal cells of the retina and cornea, retinal pigment epithelial cells, and testis. The extracellular region of FasL can be cleaved by matrix metalloproteinases (MMPs) to give rise to a 26 kD soluble protein. CD178 binds to CD95, a member of the TNFR superfamily, to induce apoptosis. CD95/CD95L interactions play an important role in the maintenance of peripheral tolerance and survival.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol FAS
Entrez