Fas/TNFRSF6/CD95 Antibody (LOB 3/17) [FITC]

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Flow Cytometry: Fas/TNFRSF6/CD95 Antibody (LOB 3/17) [FITC] [NB100-64115] - (Mouse anti human CD95:FITC) staining of HUT78 T cell line.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-64115
    • Availability
      Product Discontinued

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Fas/TNFRSF6/CD95 Antibody (LOB 3/17) [FITC] Summary

Immunogen
Fusion protein comprising extracellular domain of human Fas linked to human Fc.
Specificity
Recognizes the human CD95 cell surface antigen, a 40-50kD glycoprotein expressed by activated T and B cells, NK cells and thymocytes.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FAS
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Positive Control
Fas/TNFRSF6/CD95 Lysate (NBL1-10598)

Reactivity Notes

Reacts with Rhesus Monkey and Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Concentration
0.1 mg/ml
Purity
Protein A purified

Alternate Names for Fas/TNFRSF6/CD95 Antibody (LOB 3/17) [FITC]

  • Apo-1 antigen
  • Apo-1
  • apoptosis antigen 1
  • Apoptosis-mediating surface antigen FAS
  • APT1
  • APT1FASTM
  • CD95 antigen
  • CD95
  • CD95ALPS1A
  • Fas (TNF receptor superfamily, member 6)
  • Fas AMA
  • Fas antigen
  • Fas
  • FAS1
  • FASLG receptor
  • TNFRSF6
  • TNFRSF6member 6
  • tumor necrosis factor receptor superfamily member 6

Background

CD95, also known as FAS or APO1, is a 36 kDa cell surface type I membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS PAGE. CD95 is a member of the TNF receptor family, which includes TNFR1, TNFR2, CD27, CD30 and CD40. Binding of CD95 Ligand to CD95 or cross linking of CD95 by anti CD95 monoclonal antibodies leads to apoptosis of CD95 expressing cells. CD95 belongs to a subgroup of family members that have a death domain (DD) which contains 70 amino acids near the carboxyl terminal region of the molecule. The binding of adapter molecules to this DD is responsible for transmitting the death signal for apoptosis. Stimulation of CD95 results in aggregation of its DD, leading to the recruitment of FADD and caspase 8 that together with the receptor form the death inducing signaling complex (DISC). CD95/CD95L is involved in the peripheral deletion of activated mature T cells at the end of the immune response and defects in this pathway predispose to autoimmune disorders. CD95 is also involved in killing of targets such as virus infected cells or cancer cells and killing of inflammatory cells at immune privileged sites.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Diseases for Fas/TNFRSF6/CD95 Antibody (NB100-64115)

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Bioinformatics

Gene Symbol FAS
Entrez